Gene Writing™ advances genetic medicine beyond its current limitations.
In recent years, we’ve made extraordinary leaps in genetic medicine, with two pillar technologies emerging: gene therapy and gene editing. While these methods represent major advancements, they are not without significant limitations.
Nature has evolved a better way to alter genes— by harnessing this biology we can write and rewrite DNA into the genome.
RNA-based Gene Writing writes into or rewrites the genome based upon an RNA template.
DNA-based Gene Writing writes a template DNA into the genome.
Meet evolution’s greatest genomic architect: mobile genetic elements.
Mobile genetic elements are what make Gene Writing possible. They are amongst the most abundant genes in nature and play a bigger role in creating our genetic code than most realize.
Mobile genetic elements have already proven themselves to be extremely productive at engineering our genome. In fact, roughly fifty percent of our genome is comprised of mobile genetic element-derived DNA.
A more effective way to alter the genome.
Mobile genetic elements have evolved diverse ways to replicate and integrate—making it possible to write both large and small alterations to the genome.
Mobile genetic elements can integrate new DNA both randomly and at specific sequences in the genome. They replicate with various biochemistries through either a DNA or RNA intermediate.
Our Gene Writer discovery and engineering platform.
We identify and organize mobile genetic element sequences from all species across genome databases, making the data useful for Tessera's analysis pipeline.
We look at the protein and DNA signatures of mobile genetic elements and prioritize good candidates for Gene Writing.
In the lab, we test mobile genetic elements for their Gene Writing capabilities using state-of-the-art DNA synthesis, transfection, and molecular assay technologies.