Our Science

Gene Writing advances genetic medicine beyond its current limitations.

In recent years, we’ve made extraordinary leaps in genetic medicine, with two pillar technologies emerging: gene therapy and gene editing. While these methods represent major advancements, they are not without significant limitations.

Nature has evolved a better way to alter genes— by harnessing this biology we can write and rewrite DNA into the genome.

RNA-based Gene Writing writes into or rewrites the genome based upon an RNA template.

RNA Gene Writers can change base pairs, make small insertions or deletions, and integrate entire genes into the genome.

DNA-based Gene Writing writes a template DNA into the genome.

DNA Gene Writers can integrate large pieces of DNA, such as entire genes, into the genome.

Meet evolution’s greatest genomic architect: mobile genetic elements.

Mobile genetic elements are what make Gene Writing possible. They are amongst the most abundant genes in nature and play a bigger role in creating our genetic code than most realize.

Our Genome

Mobile genetic elements have already proven themselves to be extremely productive at engineering our genome. In fact, roughly fifty percent of our genome is comprised of mobile genetic element-derived DNA.

A more effective way to alter the genome.

Mobile genetic elements have evolved diverse ways to replicate and integrate—making it possible to write both large and small alterations to the genome.

Mobile genetic elements can integrate new DNA both randomly and at specific sequences in the genome. They replicate with various biochemistries through either a DNA or RNA intermediate.

In retrotransposition, mobile genetic element DNA is transcribed from a genomic origin site and then reverse transcribed into a target site in the genome.
In transposition, mobile genetic element DNA is cut out of the genomic origin site and then pasted into a target site in the genome.
In recombination, mobile genetic element DNA is directly exchanged between an origin site and a target site in the genome.

Retrotransposition

Transposition

Recombination

Our Gene Writer discovery and engineering platform.

We are creating the most effective Gene Writing technology using a combination of computational and wet-lab approaches.

Identify

We identify and organize mobile genetic element sequences from all species across genome databases, making the data useful for Tessera's analysis pipeline.

Prioritize

We look at the protein and DNA signatures of mobile genetic elements and prioritize good candidates for Gene Writing.

Test

In the lab, we test mobile genetic elements for their Gene Writing capabilities using state-of-the-art DNA synthesis, transfection, and molecular assay technologies.

The opportunity to cure previously untreatable genetic diseases.